Chemistry Nobel Prize 2022

The 2022 Nobel Prize in chemistry was awarded to Carolyn R Bertozzi, Morten Meldal and K Barry Sharpless.

They have been awarded this prize for the development of click chemistry and biorthogonal chemistry.


The field of research known as "click chemistry," which studies how molecules are put together, was originally studied by Sharpless.

The copper-catalyzed azide-alkyne cycloaddition (CuAAC), which was first introduced by Meldal and Dr. Sharpless independently of one another, is now frequently employed in disciplines including medical chemistry. The azide-alkyne Huisgen cycloaddition has been improved with the CuAAC reaction.

Bertozzi advanced the science by creating internal click reactions that function in living things. These bioorthogonal processes don't alter the cell's regular chemistry.

Click chemistry

In the functional field of "click chemistry," molecules come together rapidly and effectively, literally with a click.

A "collection of potent, highly reliable, and selective processes enabling the quick synthesis of useful novel compounds and combinatorial libraries using heteroatom linkages" is how it is described.


It is expensive and frequently results in adverse side effects and material loss to replicate reactions that involve the bonds between carbon atoms, which are necessary for life to exist.

Dr. Sharpless's study focuses on exploiting smaller molecules that already have a full carbon frame rather than trying to cause reactions between carbon atoms. The use of oxygen or nitrogen atoms as bridges can further connect these molecules.

The loss of material as well as the undesirable side reactions may be avoided in simpler processes "where there is a strong inherent motivation for the molecules to link together."

Posted by V.P.Nimbalkar on 6th Oct 2022